Endocrine Abstracts

Introduction: Autoantibodies (aAB) are characteristic of autoimmune diseases, but may also be found in apparently healthy individuals and precede pathological symptoms. We have recently reported on autoantibodies against the IGF1-receptor (IGF1R-aAB) in control subjects and patients with Graves’ disease (1). The isolated aAB were able to immunoprecipitate the recombinant autoantigen and antagonized IGF1 signaling in vitro. Given the structural similarities betwee...

Objective: Insulin-like growth factor 1 (IGF1) has a crucial role in growth and metabolism. A specifically designed autoantibody (aAb) assay against the IGF1 receptor (IGF1R-aAb) is able to detect IGF1R-aAb in serum. As the IGF1R has shown involvement in many functional pathologies (e.g. in the Laron syndrome), we aimed to investigate the role of IGF1R-aAb in a large population-based cohort of middle-aged volunteers and their potential effects on anthropometric, osteological a...